Newly designed punch for scored tablets: Evaluation by an expert system based on quality by design

Scored tablets enable modulation of the drug dose and intake by elderly, pediatric dysphagic patients. However, they are known to involve difficulties in splitting, problems mass uniformity portions loss on breaking. A new punch designed for manufacturing convex-faced cylindrical easy-breakable (EBTs) was proposed. The upper exhibited a pronounced cross ridge two curvatures, peripheral one having lower radius, allow section small area be split better exploitation applied force. Punches 8 mm diameter were used orally disintegrating (ODTs), four most common co-processed ODT excipients employed explore versatility investigated punch. For this purpose, an expert system constructed based 10 selected critical quality attributes, namely bulk density, compressibility index cohesion powder formulations as well uniformity, crushing strength, friability, breakability index, disintegration time, wetting time percentage water uptake tablets. Experimental data relevant these parameters normalized radius values 0–10 range, 5 being minimum acceptable. By connecting such values, radar diagrams drawn. shape along with calculated indices overall pointed out suitability robust performance EBT manufacturing.